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About Us

Drug Discovery Initiative, DDI, was established to contribute to our health through the elucidation of life phenomena and the discovery of new drug leads. DDI is a hub of national collaborative research networks for drug discovery based on our public chemical library. DDI promotes open innovation by providing advice, technical support and chemical samples to the researchers who need to screen chemical samples. DDI also provides chemical synthesis and pharmacokinetic research support for lead compound generation.

Contact Us

Drug Discovery Initiative, Graduate School of Pharmaceutical Sciences,

The University of Tokyo

7-3-1 Hongo, Bunkyo-ku, Tokyo 113-0033, Japan

Telephone: +81-3-5841-1960

Facsimile: +81-3-5841-1959

E-mail: ddiinfomol.f.u-tokyo.ac.jp

Member

Director, Hidenori Ichijo, D.D.S., Ph.D.
Deputy Director, Hirotatsu Kojima, Ph.D
Professor, Hiroyuki Miyachi, Ph.D. (LEU)
Associate Professor, Toru Iijima, Ph.D. (LEU)
Associate Professor, Kosuke Yasuda, Ph.D. (LEU)
Lecturer, Takuya Ikeda, Ph.D. (LEU)
Lecturer, Riyo Imamura, Ph.D.
Lecturer, Kayoko Kanamitsu, Ph.D. (LEU)
Lecturer, Mari Takamiya, Ph.D.
Member, Tomoko Futamata
Member, Tsukasa Hasegawa, M.S.
Member, Kiyoe Hayashi
Member, Chinatsu Honma, M.S.
Member, Yoshiko Inoue (LEU)
Member, Mayumi Ishii (LEU)
Member, Chie Coda
Member, Izumi Minegishi
Member, Junko Sasaki (LEU)
Member, Chie Sugita (LEU)
Member, Naoki Suto, Ph.D. (LEU)
Member, Masashi Suzuki, Ph.D. (LEU)
Member, Natsue Taketa
Member, Eri Watanabe (LEU)
Staff, Zubeda Begum, Ph.D. (LEU)
Staff, Hazuki Tanaka, M.S.
Visiting Professor, Yoichi Kurebayashi, D.V.M., Ph.D. (LEU)
Visiting Professor, Takayoshi Okabe, Ph.D.

Management Committee

Hidenori Ichijo, D.D.S., Ph.D.

Junken Aoki, Ph.D.

Hirotatsu Kojima, Ph.D.

Masayuki Miura, Ph.D.

Hiroyuki Miyachi, Ph.D.

Shigeo Murata, M.D., Ph.D.

Taisuke Tomita, Ph.D.

Yasuteru Urano, Ph.D.

Kosuke Yasuda, Ph.D.

History and Aim of DDI

A public chemical library is an important research platform for the development of synthetic small molecules that regulate biological functions. Hit compounds can be identified by high-throughput screening of the library. Optimization studies are then performed to create the lead compounds with more selectivity, higher activity and better ADMET properties. For a long time, however, there was no large-scale public chemical library in Japan.

In 2006, Chemical Biology Research Initiative, CBRI, was established in the University of Tokyo with the aim of contributing to the development of life science research and applying the results of basic research in academia to industry. In parallel with building the chemical library, we provided compound samples to researchers nationwide who need them.

In 2011, we set a new goal to further develop research activities based on the established chemical library in collaboration with research groups in a wide range of fields within and outside the university, and renamed the organization Open Innovation Center for Drug Discovery, OCDD, to provide comprehensive support from hit compound discovery to lead compound generation.

In addition, in 2015, the organization was renamed Drug Discovery Initiative, DDI, to further enhance the chemical library with samples deposited by pharmaceutical companies, and Lead Exploration Unit (LEU) was newly established in DDI to be responsible for generating lead compounds, thereby developing activities to contribute to the Healthcare Policy promoted by the government.

In 2022, DDI was reorganized as an affiliated organization of Graduate School of Pharmaceutical Sciences, and at the same time, DDI was accepted into the BINDS project (Phase II) of Japan Agency for Medical Research and Development, AMED, to continue our drug discovery research support based on the know-how of people with research experience in industry and past experience in supporting drug discovery research in academia.

As shown in the schematic diagram, “synthetic compounds that regulate biological functions” will be efficiently created by promoting collaboration among research groups in various fields such as organic synthetic chemistry, medical science, analytical chemistry, biophysics and life science. DDI aims to promote active collaboration within and outside the university.

Chemical Library

Screening Systems

Infrastructure

Providing Samples

Our Network

Since April 2017

Old Projects

Target Proteins Research Program Leading-edge Research Infrastructure Program Platform for Drug Discovery, Informatics, and Structure Life Sciences